AccessibilityAttack/Destroy and Use Item/Place Block can be set to Hold or Toggle, with new Invert Mouse X and Sprint Window options.
PerformanceFixed spawn chunks are gone: chunks for forceloading, portals, Ender Pearls and the player's area load before joining, with a progress bar.
ServersThe allow-nether, spawn-monsters, enable-command-block and pvp server properties became game rules, and servers can require players to accept a code of conduct.
ServersNew Minecraft Server Management Protocol: a JSON-RPC 2.0 API over WebSocket, off by default, to manage players, the allowlist, operators and game rules.
GraphicsOpenGL 3.3 is now required instead of 3.2, and particles outside the player's view are no longer rendered.
BlocksThe Chain is renamed Iron Chain, and Lightning Rods now oxidise like other copper blocks.
TechnicalData pack version 88.0 and resource pack version 69.0. Pack versions now have minor numbers, and pack.mcmeta uses min_format and max_format.